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Planta Med 1997; 63(1): 63-65
DOI: 10.1055/s-2006-957606
Papers
Phytochemical Analysis
© Georg Thieme Verlag Stuttgart · New York

Piper methysticum: Enantiomeric Separation of Kavapyrones by High Performance Liquid Chromatography*

Hanns Häberlein, Georg Boonen, Mona-Antonia Beck
  • Institut für Pharmazeutische Biologie der Philipps-Universität, Deutschhausstr. 17A, D-35032 Marburg, Germany
Dedicated to Professor Dr. G. Seitz on the occasion of his 60th birthday.
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Publication History

1996

1996

Publication Date:
04 January 2007 (online)

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Abstract

A simultaneous separation of the enantiomers of kawain, dihydrokawain, methysticin, and dihydromethysticin as well as the achiral dienolides yangonin and demethoxyyangonin was carried out on a ChiraSpher® NT column. This HPLC method can be used for the investigation of the enantiomeric purity of plant material and herbal medicines. The influence of temperature and flow rate are discussed in respect to the chromatographic resolution of the enantiomers. All tested enolide racemates can be preparatively separated on ChiraSpher® NT.

Key words

Piper methysticum Forst. - Piperaceae - Kava-Kava - kavapyrones - HPLC - enantiomers