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Planta Med 1997; 63(1): 31-35
DOI: 10.1055/s-2006-957598
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Pharmacology and Molecular Biology
© Georg Thieme Verlag Stuttgart · New York

Smooth Muscle Relaxing Flavonoids and Terpenoids from Conyza filaginoides*

R. Mata1 , A. Rojas2 , L. Acevedo1 , S. Estrada1 , F. Calzada3 , I. Rojas2 , R. Bye4 , E. Linares4
  • 1Departamento de Farmacia, Facultad de Química and Unidad de Investigación en Plantas Medicinales, Instituto de Química and Facultad de Química, Universidad Nacional Autónoma de México, Coyoacán 04510, México D.F.
  • 2Facultad de Química, Universidad Autónoma de Querétaro, Centro Universitario 7610, Querétaro, México
  • 3Unidad de Investigación Médica en Farmacología de Productos Naturales, Hospital de Pediatría del Centro Médico Nacional Siglo XXI, IMSS, México D.F.
  • 4Jardín Botánico, Instituto de Biología, Universidad Nacional Autónoma de México, Coyoacán 04510, México D.F.
Chemical Studies on Mexican Plants Used in Traditional Medicine XXXIII. Taken in part from the BS theses of L. Acevedo and S. Estrada
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Publication History

1996

1996

Publication Date:
04 January 2007 (online)

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Abstract

Activity-guided fractionation of the smooth muscle relaxing, chloroform-methanol (1:1) extract of Conyza filaginoides (D.C.) Hieron (Asteraceae) led to the isolation of three flavonoids (quercetin 3-glucoside, rutin, and pinostrobin), one sterol (α-spi-nasterol), a sesquiterpenoid (β-caryophyllene 4,5-α-oxide), and two triterpenoids (erythrodiol and 3-β-tridecanoyloxy-28-hydroxyolean-12-ene). 3-β-Tridecanoyloxy-28-hydroxy-olean-12-ene is a new naturally occurring terpenoid. All the isolated compounds induced a concentration-dependent inhibition of the spontaneous contractions of rat ileum. The spasmolytic activity exhibited by the extract and active principles tends to support the traditional use of C. filaginoides as an antispasmodic agent.

Key words

Conyza filaginoides - Asteraceae - quercetin 3-glucoside - rutin - pinostrobin - α-spinasterol - β-caryophyllene 4,5-α-oxide - erythrodiol - 3-β-tridecanoyloxy-28-hydroxyolean-12-ene - smooth muscle relaxation - spasmolytic effect - rat ileum