Planta Med 1998; 64(8): 752-754
DOI: 10.1055/s-2006-957573

© Georg Thieme Verlag Stuttgart · New York

Cytotoxic Sesquiterpene Lactones from Inula britannica

Eun Jung Park, Jinwoong Kim
  • College of Pharmacy, Seoul National University, Seoul, Korea
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Publication History



Publication Date:
04 January 2007 (online)


Cytotoxicity-guided fractionation of the flowers of Inula britannica led to the isolation of four sesquiterpene lactones, 4α,6α-dihydroxyeudesman-8β,12-olide (1), ergolide (2), 8-epi-helenalin (3), and bigelovin (4). Compound 1 was isolated as a new natural product. These compounds showed cytotoxicity against human tumor cell lines.