Antimycobacterial Matricaria Esters and Lactones from Astereae Species

Abstract

Six matricaria esters (MEs) and two matricaria lactones (MLs), isolated from members of the tribe Astereae (Asteraceae), were tested against Mycobacterium tuberculosis and M. avium, using a radiorespirometric bioassay. (2Z,8Z)-ME and (2E-8Z)-ME gave minimum inhibitory concentrations (MICs) of 50 µg ml^-1 against M. tuberculosis and respective MICs of 25 and 50 µg ml^-1 against M. avium. The (4Z,8Z)-ML, (2Z)-8-dehydro-ME and (2Z,8Z)-10-angeloyloxy-(2Z,8Z)-ME showed respective MICs of 12.5, 25, 25 µg ml^-1 against M. tuberculosis and MICs of 50, 25, 25 µg ml^-1 against M.avium, respectively. The MICs of (2Z-8Z)-10-tigloyloxy-ME and (2E,8Z)-10-angeloyloxy-ME and (4E,8Z)-ML ranged from 50 to > 100 µg ml^-1 against both pathogenic mycobacteria.