© Georg Thieme Verlag Stuttgart · New York
Tribulusamide A and B, New Hepatoprotective Lignanamides from the Fruits of Tribulus terrestris: Indications of Cytoprotective Activity in Murine Hepatocyte Culture
04 January 2007 (online)
Tribulusamides A (1) and B (2), new lignanamides embracing two cinnamic amide parts joined in a cis configuration, were isolated from the fruits of Tribulus terrestris, together with four known compounds, N-trans-feruloyltyramine (3), terrestriamide (4), N-trans-coumaroyltyramine (5), and β-sitosterol. The structures were elucidated by 2D-NMR spectroscopy. Addition of compounds 1-5, especially 1 and 2, to primary cultured mouse hepatocytes significantly prevented cell death induced by D-galactosamine (D-GalN)/tumor necrosis factor α (TNF-α).
Tribulus terrestris - Zygophyllaceae - lignanamide - tribulusamide - D-galactosamine - tumor necrosis factor α (TNF-α) - hepatoprotective activity