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Planta Med 1998; 64(7): 598-602
DOI: 10.1055/s-2006-957529
Paper
Pharmacology
© Georg Thieme Verlag Stuttgart · New York

(+)-Rhododendrol and epi-Rhododendrin Suppress the NO Production by Activated Macrophages in vivo

Shinji Fushiya, Yasuaki Kabe, Yasuaki Ikegaya, Fumihide Takano
  • Faculty of Pharmaceutical Sciences, Tohoku University, Aramaki-Aza-Aobayama, Aoba-Ku, Sendai, Japan
Further Information

Publication History

1997

1998

Publication Date:
04 January 2007 (online)

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Abstract

In this study, we investigated the effect of (+)-rhododendrol (1) and epi-rhododendrin (2) isolated from Acer nikoense Maxim. (Aceraceae) on nitric oxide (NO) production in mouse peritoneal macrophages elicited by bacillus Calmette-Guérin and in vitro stimulated by lipopolysaccharide. The NO production was not affected by an oral administration of methanol extract at a dose of l00 mg/kg/day. However, the AcOEt soluble fraction significantly reduced the NO production. (+)-Rhododendrol (1) isolated as an active substance from the AcOEt fraction suppressed the NO production. epi-Rhododendrin (2), the glucoside of (+)-rhododendrol (1) isolated from the n-BuOH fraction, also suppressed the NO production. As NO is one of the critical mediators in inflammation, these results suggest that (+)-rhododendrol (1) and epi-rhododendrin (2) contribute in part to the anti-inflammatory effect of A. nikoense.

Key words

Acer nikoense - Aceraceae - (+)-rhododendrol - epi-rhododendrin - nitric oxide - inflammation - macrophage

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