Planta Med 1998; 64(5): 404-407
DOI: 10.1055/s-2006-957469
© Georg Thieme Verlag Stuttgart · New York

Anti-Inflammatory Activity of Unusual Lupane Saponins from Bupleurum fruticescens

María J. Just1 , M. Carmen Recio1 , Rosa M. Giner1 , María J. Cuéllar1 , Salvador Máñez1 , Anna R. Bilia2 , José-Luis Ríos1
  • 1Department de Farmacologia, Universitat de València, Burjassot, Spain
  • 2Dipartimento di Chimica Bioorganica, Università di Pisa, Pisa, Italy
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Publication History



Publication Date:
04 January 2007 (online)


Extracts from Bupleurum fruticescens were examined for oral and topical anti-inflammatory activities. The BuOH extract proved to be active against carrageenan and tetradecanoylphorbol acetate acute edemas and allowed the isolation of three saponins identified by spectroscopic techniques as 3β-O-(O-α-L-rhamnopyranosyl-(1→4)-O[β-D-glucopyranosyl-(1→6)]-O-β-D-glucopyranosyl)lup-20(29)-ene-23,28-dioic acid (fruticesaponin A), 3β-O-(O-α-L-rhamnopyranosyl-(1→4)-O-β-D-glucopyranosyl)lup-20(29)-ene-23,28-dioic acid 28-O-β-D-glucopyranosyl ester (fruticesaponin B), and 3β-O-(O-α-L-rhamnopyranosyl-(1→4)-O-[β-D-glucopyranosyl-(1→6)]-O-β-D-glucopyranosyl)lup-20(29)-ene-23,28-dioic acid 28-O-β-D-glucopyranosyl ester (fruticesaponin C). These compounds were studied against carrageenan, tetradecanoylphorbol acetate, arachidonic acid and ethyl phenylpropiolate acute edemas. Fruticesaponin B, a bidesmosidic saponin with an unbranched saccharide moiety was the most active in all the tests applied.