Planta Med 1998; 64(4): 373-374
DOI: 10.1055/s-2006-957455

© Georg Thieme Verlag Stuttgart · New York

Amentoflavone from Biophytum sensitivum and its Effect on COX-1/COX-2 Catalysed Prostaglandin Biosynthesis

Franz Bucar1 , Sanjay M. Jachak1 , Ylva Noreem2 , Theodor Kartnig1 , Premila Perera2 , Lars Bohlin2 , Manfred Schubert-Zsilavecz3
  • 1Institute of Pharmacognosy, University of Graz, Graz, Austria
  • 2Division of Pharmacognosy, Biomedical Centre, Uppsala University, Uppsala, Sweden
  • 3Institute of Pharmaceutical Chemistry, University of Frankfurt am Main, Frankfurt am Main, Germany
Further Information

Publication History



Publication Date:
04 January 2007 (online)


Amentoflavone (13′, ll8-biapigenin) was isolated from the roots of Biophytum sensitivum DC. (Oxalidaceae) and proved to be a selective inhibitor of cyclooxygenase (COX)-1 catalysed prostaglandin biosynthesis when tested in vitro with an IC50 value of 12.4 µM (standard: indomethacin, IC50 = 1.1 µM). Doses of up to 37 µM showed only a slight inhibition in the corresponding COX-2 assay. Quantification of amentoflavone was carried out by reversed phase HPLC in methanolic and aqueous extracts of the roots, stems and leaves. Highest amounts of amentoflavone were detected in methanolic extracts of roots and stems (0.26-0.35%), while considerably lower amounts were detected in the corresponding water extracts.