Planta Med 1998; 64(4): 362-366
DOI: 10.1055/s-2006-957452
Natural Product Chemistry
© Georg Thieme Verlag Stuttgart · New York

Two Epimeric Pairs of C-4-Acetyl Annonaceous Acetogenins from Goniothalamus donnaiensis

Zhong Jiang, Ruo-Yun Chen, Ying Chen, De-Quan Yu
  • Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China
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Publication History



Publication Date:
04 January 2007 (online)


Further studies on the roots of Goniothalamus donnaiensis Finet et Gagnap (Annonaceae) led to the isolation of two pairs of Annonaceous acetogenins, donnaienin C (1) and 34-epi-donnaienin C (1′), donnaienin D (2) and 34-epi-donnaienin D (2′), containing a rare γ-hydroxymethyl-γ-lactone moiety and a C-4-acetoxy group. Their structures were elucidated by spectral data and chemical derivatization. Preliminary pharmacological tests showed that the mixture of donnaienin C(1) and 34-epi-donnaienin C (1′) inhibited human hepatoma (Bel) cell lines in vitro (IC50, 7.1 µg/ml).