Antinociceptive and anti-inflammatory effects of limonin isolated from the dried fruits
of Evodia rutaecarpa var. bodinieri were investigated. Oral administration of 30 or 100mg/kg limonin significantly decreased
the frequency of licking and biting behavior within a unit of time at the late phase
without affecting that of the early phase in the formalin test. Limonin inhibited
the rise of vascular permeability induced by acetic acid and the increase of paw edema
induced by carrageenin. Limonin also showed inhibitory effects on bradykinin induced
paw edema and arachidonic acid-induced ear swelling. These results suggest that limonin
possesses an antinociceptive effect and the effect may be accompanied by an anti-inflammatory
action, and that the antinociceptive activity in Evodiae Fructus is partially attributable
to limonin.
Evodia rutaecarpa var. bodinieri
- Evodiae Fructus - Rutaceae - antinociceptive activity - anti-inflammatory activity
- limonin
