Planta Med 1998; 64(4): 339-342
DOI: 10.1055/s-2006-957447
Papers
Pharmacology
© Georg Thieme Verlag Stuttgart · New York

Antinociceptive and Anti-Inflammatory Activities of Limonin Isolated from the Fruits of Evodia rutaecarpa var. bodinieri

H. Matsuda1 , M. Yoshikawa1 , M. linuma2 , M. Kubo1
  • 1Faculty of Pharmaceutical Sciences, Kinki University, Osaka, Japan
  • 2Gifu Pharmaceutical University, Gifu, Japan
Further Information

Publication History

1997

1997

Publication Date:
04 January 2007 (online)

Abstract

Antinociceptive and anti-inflammatory effects of limonin isolated from the dried fruits of Evodia rutaecarpa var. bodinieri were investigated. Oral administration of 30 or 100mg/kg limonin significantly decreased the frequency of licking and biting behavior within a unit of time at the late phase without affecting that of the early phase in the formalin test. Limonin inhibited the rise of vascular permeability induced by acetic acid and the increase of paw edema induced by carrageenin. Limonin also showed inhibitory effects on bradykinin induced paw edema and arachidonic acid-induced ear swelling. These results suggest that limonin possesses an antinociceptive effect and the effect may be accompanied by an anti-inflammatory action, and that the antinociceptive activity in Evodiae Fructus is partially attributable to limonin.