Torilin, a Sesquiterpene from Torilis japonica, Reverses Multidrug-Resistance in Cancer Cells

Se Eun Kim; Young Ho Kim; Young Choong Kim; Jung Joon Lee

doi:10.1055/s-2006-957445

Planta Medica, Table of Contents

Planta Med 1998; 64(4): 332-334
DOI: 10.1055/s-2006-957445

Papers

Pharmacology
© Georg Thieme Verlag Stuttgart · New York

Torilin, a Sesquiterpene from Torilis japonica, Reverses Multidrug-Resistance in Cancer Cells

Se Eun Kim¹ , Young Ho Kim¹ ^, ³ , Young Choong Kim² , Jung Joon Lee¹

¹Natural Product Biosynthesis RU., Korea Research Institute of Bioscience and Biotechnology, Yusong, Taejon, Korea
²College of Pharmacy, Seoul National University, Seoul, Korea
³College of Pharmacy, Chungnam National University, Taejon, Korea

Abstract

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Abstract

A sesquiterpene compound reversing multidrug-resistance in cancer cells was isolated from the fruits of Torilis japonica and the structure was identified as torilin. Torilin potentiated the cytotoxicities of adriamycin, vinblastine, taxol and colchicine against multidrug-resistant KB-V1 and MCF7/ADR cells.

Key words

Torilis japonica - Umbelliferae - torilin - sesquiterpene - multidrug-resistance (MDR)

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