Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000058.xml
Planta Med 1998; 64(3): 281-282
DOI: 10.1055/s-2006-957429
DOI: 10.1055/s-2006-957429
Letters
Letter
© Georg Thieme Verlag Stuttgart · New York
Xanthones with Antimalarial Activity from Garcinia dulcis
Further Information
Publication History
1997
1997
Publication Date:
04 January 2007 (online)
Abstract
Chromatographic separation of the EtOH extract of the bark of Garcinia dulcis (Guttiferae) furnished five xanthones, viz 1,7-dihydroxyxanthone (1), 12b-hydroxy-des-D-garcigerrin A (2), 1-O-methylsymphoxanthone (3), symphoxanthone (4), and garciniaxanthone (5). These xanthones 1-5 showed inhibitory effects on the growth of Plasmodium falciparum with IC50 values of 0.96-3.88 µg/ml. In addition, revised 13C-NMR assignments of 3 and complete 13C-NMR assignments of 4 were obtained through analysis of their COSY, NOESY, HMQC, and HMBC spectra.