Xanthones with Antimalarial Activity from Garcinia dulcis

Kittisak Likhitwitayawuid; Wisinee Chanmahasathien; Nijsiri Ruangrungsi; Jerapan Krungkrai

doi:10.1055/s-2006-957429

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Planta Med 1998; 64(3): 281-282
DOI: 10.1055/s-2006-957429

Letters

Letter
© Georg Thieme Verlag Stuttgart · New York

Xanthones with Antimalarial Activity from Garcinia dulcis

Kittisak Likhitwitayawuid¹ , Wisinee Chanmahasathien¹ ^, ³ , Nijsiri Ruangrungsi¹ , Jerapan Krungkrai²

¹Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand
²Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
³Present address: Department of Pharmacognosy, Faculty of Pharmacy, Chiangmai University, Thailand

Further Information

Publication History

1997

1997

Publication Date:
04 January 2007 (online)

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Abstract

Chromatographic separation of the EtOH extract of the bark of Garcinia dulcis (Guttiferae) furnished five xanthones, viz 1,7-dihydroxyxanthone (1), 12b-hydroxy-des-D-garcigerrin A (2), 1-O-methylsymphoxanthone (3), symphoxanthone (4), and garciniaxanthone (5). These xanthones 1-5 showed inhibitory effects on the growth of Plasmodium falciparum with IC₅₀ values of 0.96-3.88 µg/ml. In addition, revised ¹³C-NMR assignments of 3 and complete ¹³C-NMR assignments of 4 were obtained through analysis of their COSY, NOESY, HMQC, and HMBC spectra.

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