Planta Med 1998; 64(3): 246-250
DOI: 10.1055/s-2006-957419
Papers
Natural Product Chemistry
© Georg Thieme Verlag Stuttgart · New York

Angiotensin Converting Enzyme (ACE) Inhibitors from Jasminum azoricum and Jasminum grandiflorum

Brinda Somanadhan1 , 2 , Ulla Wagner Smitt1 , V. George2 , P. Pushpangadan2 , S. Rajasekharan2 , Jens Ø. Duus3 , Ulf Nyman1 , Carl Erik Olsen4 , Jerzy W. Jaroszewski1
  • 1Department of Medicinal Chemistry, The Royal Danish School of Pharmacy, Copenhagen, Denmark
  • 2Tropical Botanic Garden and Research Institute, Pacha-Palode, Trivandrum, Kerala, India
  • 3Carlsberg Laboratory, Department of Chemistry, Valby, Denmark
  • 4Department of Chemistry, Royal Veterinary and Agricultural University, Frederiksberg, Denmark
Further Information

Publication History

1997

1997

Publication Date:
04 January 2007 (online)

Abstract

Bioactivity-guided fractionation of extracts of the aerial parts of Jasminum azoricum var. travancorense, using an in vitro ACE inhibition assay, led to isolation of three oligomeric, iridoid-type compounds, which were named sambacein I-III. Their structures are based on spectroscopic and chemical evidence. Similarly, fractionation of extracts of aerial parts of J. grandiflorum resulted in the isolation of the previously reported ACE inhibitor, oleacein. The IC50 values of purified ACE inhibitors were 26-36 µM. Moreover, 2-(3,4-dihydroxyphenyl)-ethanol, isoquercitrin and ursolic acid were isolated from J. grandiflorum. Sambaceins and oleacein are formed from genuine iridoid glucosides during processing of the plant material. NMR spectroscopy was used to measure the level of the ACE inhibitors in the traditional medicines prepared in Kerala from these Jasminum species.