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Planta Med 1998; 64(3): 242-245
DOI: 10.1055/s-2006-957418
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Natural Product Chemistry
© Georg Thieme Verlag Stuttgart · New York

A New Epimeric Pair of Mono-THF Annonaceous Acetogenins from Goniothalamus gardneri

Ying Chen, Ruo Run Chen, Zhong Jiang, De Quan Yu
  • Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China
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Publication History

1997

1997

Publication Date:
04 January 2007 (online)

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Abstract

From the roots of Goniothalamus gardneri Hook f. et. Thoms (Annonaceae), we have isolated a novel epimeric pair, gardnerinin (1) and 34-epi-gardnerinin (1′), characterized by the presence of a γ-hydroxymethyl-γ-lactone moiety. These compounds represent an unusual type of mono-THF Annonaceous acetogenins, bearing one flanking hydroxy group on the hydrocarbon side, and another hydroxy group on the lactone side, that is only one carbon away from the THF ring.

Key words

Goniothalamus gardneri - Annonaceae - acetogenin - gardnerinin - 34-epi-gardnerinin