Antimalarial Naphthoquinones from Nepenthes thorelii

Kittisak Likhitwitayawuid; Rawiwun Kaewamatawong; Nijsiri Ruangrungsi; Jerapan Krungkrai

doi:10.1055/s-2006-957417

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Planta Med 1998; 64(3): 237-241
DOI: 10.1055/s-2006-957417

Papers

Pharmacology
© Georg Thieme Verlag Stuttgart · New York

Antimalarial Naphthoquinones from Nepenthes thorelii

Kittisak Likhitwitayawuid¹ , Rawiwun Kaewamatawong¹ ^, ³ , Nijsiri Ruangrungsi¹ , Jerapan Krungkrai²

¹Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand
²Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
³Present adress: Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Ubon Ratchathani University, Thailand

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Publication History

1997

1997

Publication Date:
04 January 2007 (online)

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Abstract

Roots of Nepenthes thorelii yielded plumbagin, 2-methylnaphthazarin, octadecyl caffeate, isoshinanolone, and droserone. In addition, seven derivatives were prepared from plumbagin. Each of these natural and semisynthetic compounds was evaluated for in vitro antimalarial potential.

Key words

Nepenthes thorelii - Nepenthaceae - naphthoquinone - antimalarial activity