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Planta Med 1998; 64(3): 229-232
DOI: 10.1055/s-2006-957415
Papers
Pharmacology
© Georg Thieme Verlag Stuttgart · New York

The Selective Antianginal Effect without Changing Blood Pressure of Butylidenephthalide in Conscious Rats

Wun-Chang Ko1 , 3 , Joen-Rong Sheu1 , Shu-Huey Tzeng1 , Chi-Ming Chen2 , 3
  • 1Graduate Institute of Medical Sciences, Taipei Medical College, Taipei, Taiwan, R.O.C.
  • 2School of Pharmacy, Taipei Medical College, Taipei, R.O.C.
  • 3National Research Institute of Chinese Medicine, Taipei, Taiwan, R.O.C.
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Publication History

1997

1997

Publication Date:
04 January 2007 (online)

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Abstract

Synthetic butylidenephthalide (Bdph), 60mg/kg per os (p.o.) given 3 h prior to injection of pituitrin (4 U/kg, i.v.), significantly prevented T-wave lowering on lead II electrocardiograph in unanesthetized rats. The effective dose, 60mg/kg, was about 1/56th of the median lethal dose (LD50, p.o.) in rats. However, Bdph (60 mg/kg, p.o.) did not affect systolic pressure and heart rate in unanesthetized rats. Therefore, Bdph, found in the rhizome of Ligusticum chuaxiong Hort. (L. wallichii Franch., Umbelliferae), appears to have selective antianginal effect without changing blood pressure and heart rate.

Key words

Ligusticum chuaxiong Hort. - Ligusticum wallichii Franch. - Umbelliferae - butylidenephthalide - antianginal effects - myocardial ischemia - pituitrin - T-wave lowering