Cytotoxic Activity of Labdane Type Diterpenes Against Human Leukemic Cell Lines in vitro

Kostas Dimas; Costas Demetzos; Marios Marsellos; Roula Sotiriadou; Mixalis Malamas; Dimitrios Kokkinopoulos

doi:10.1055/s-2006-957410

Planta Medica, Table of Contents

Planta Med 1998; 64(3): 208-211
DOI: 10.1055/s-2006-957410

Papers

Pharmacology
© Georg Thieme Verlag Stuttgart · New York

Cytotoxic Activity of Labdane Type Diterpenes Against Human Leukemic Cell Lines in vitro

Kostas Dimas¹ , Costas Demetzos² , Marios Marsellos³ , Roula Sotiriadou¹ , Mixalis Malamas³ , Dimitrios Kokkinopoulos¹

¹Hellenic Anticancer Institute, Dept. of Immunology, Athens, Greece
²Laboratory of Pharmacognosy, School of Pharmacy, University Campus, Athens, Greece
³Department of Pharmacology, University of loannina Medical School, loannina, Greece

Abstract

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Abstract

Nine labdane type diterpenes isolated from the plant Cistus creticus subsp. creticus and from the resin “Ladano” which is excreted on the surface of the leaves and stems of this plant, were examined for their in vitro cytotoxic activity against 14 human leukemic cell lines. Compound 1, (13E)-labd-13-ene-8α,15-diol, exhibited cytotoxic activity against 13 of the cell lines tested, while compound 2, (13E)-labd-7,13-dienol, was active only against HL60 cells. Further compound 1 was examined for its effect on the uptake of [³ H]-thymidine as a marker of DNA synthesis.

Key words

Cistus creticus Cistaceae - labdane diterpenes - Ladano - cytotoxicity - DNA synthesis

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