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DOI: 10.1055/s-2006-957409
© Georg Thieme Verlag Stuttgart · New York
α-Viniferin: A Prostaglandin H2 Synthase Inhibitor from Root of Carex humilis
Publication History
1997
1997
Publication Date:
04 January 2007 (online)
Abstract
An inhibitor on cyclooxygenase activity of prostaglandin H2 synthase was purified from the root of Carex humilis Leyss (Cyperaceae) by a variety of column chromatographic methods. As a result of the structure analysis by FAB-mass, 1H-NMR, and 13C-NMR spectral data, the active compound was identified as (+)-α-viniferin, an oligomeric stilbene characterized originally from Caragana chamlagu Lamarck (Legumino-sae). (+)-α-Viniferin exhibited a dose-dependent inhibition on cyclooxygenase activity, where 50% of inhibition (IC50) was shown at a final concentration of about 7 µM. Resveratrol, a putative building block of oligomeric stilbenes, also inhibited the cyclooxygenase activity. The inhibitory potency of (+)-α-viniferin was about 3- to 4-fold stronger than that of resveratrol on cyclooxygenase activity of prostaglandin H2 synthase partially purified from sheep seminal vesicles.
Key words
Carex humilis - Cyperaceae - (+)-α-viniferin - prostaglandin H2 synthase inhibitor