Abstract
Two alkamides E,E-2,4-octadienamide and E,Z-2,4-decadienamide have been isolated from Phyllanthus fraternus, a plant used in Ghanaian traditional medicine to treat malaria. The compounds possess
an α,β,γ,δ-unsaturated conjugated amide, a feature believed to enhance antiplasmodial
activity. By means of an in vitro assay the two alkamides have been shown to possess moderate antiplasmodial activity.
