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Planta Med 1998; 64(2): 174-176
DOI: 10.1055/s-2006-957398
Letters
Letter
© Georg Thieme Verlag Stuttgart · New York

Cytotoxic Coumarins from the Aerial Parts of Tordylium apulum and their Effects on a Non-Small-Cell Bronchial Carcinoma Cell Line

Constantinos Kofinas1 , loanna Chinou1 , Anargiros Loukis1 , Catherine Harvala1 , Christos Roussakis2 , Marc Maillard3 , Kurt Hostettmann3
  • 1Division of Pharmacognosy, University of Athens, Athens, Greece
  • 2ISOMER Laboratoire de Pharmacognosie Marine, Universite de Nantes, Faculte de Pharmacie, Nantes, France
  • 3Institute de Pharmacognosie et Phytochimie, Universite de Lausanne, Lausanne, Switzerland
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Publication History

1997

1997

Publication Date:
04 January 2007 (online)

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Abstract

Seven coumarins were isolated from the aerial parts of Tordylium apulum; their structures were established by spectroscopic means. All compounds were tested in vitro for their cytotoxicity against two cell line systems. The antiproliferative effects for three of them were studied at the level of the cell cycle in asynchronous cells of the NSCLC-N6 line with a flow cytometry apparatus.