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DOI: 10.1055/s-2006-957394
© Georg Thieme Verlag Stuttgart · New York
Three New Flavonoids and Antiallergic, Anti-Inflammatory Constituents from the Heartwood of Dalbergia odorifera
Publication History
1997
1997
Publication Date:
04 January 2007 (online)
Abstract
Three new flavonoids, (3R)-4′-methoxy-2′,3,7-trihydroxyisoflavanone (11), 7-methoxy-3,3′,4′,6-tetrahydroxyflavone (18), and 2′,7-dihydroxy-4′,5′-dimethoxyisoflavone (22), were isolated from the heartwood of Dalbergia odorifera T. Chen. (Leguminosae), together with twenty-two known compounds, (S)-4-methoxydalbergione (1), cearoin (2), medicarpin (3), formononetin (4), sativanone (5), 3-hydroxy-9-methoxy-coumestan (6), meliotocarpan A (7), isoliquiritigenin (8), stevein (9), liquiritigenin (10), 3′,4′,7-trihydroxyflavanone (12), butein (13), 3′-hydroxymelanettin (14), koparin (15), bowdichione (16), fisetin (17), melanettin (19), sulfuretin (20), 3′-hydroxydaidzein (21), 3′-O-methylviolanone (23), xenognosin B (24), and dalbergin (25). These flavonoids were evaluated in antiallergic and anti-inflammatory tests. The results showed that (S)-4-methoxydalbergione (1) and cearoin (2) exhibited antiallergic activity while (S)-4-methoxydalbergione (1), cearoin (2), butein (13), koparin (15), bowdichione (16), 3′-O-methylviolanone (23), and xenognosin B (24) showed significant anti-inflammatory activity.
Key words
Dalbergia odorifera - Leguminosae - flavonoids - antiallergic activity - anti-inflammatory activity