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Planta Med 1998; 64(2): 120-125
DOI: 10.1055/s-2006-957387
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Pharmacology
© Georg Thieme Verlag Stuttgart · New York

Hepatoprotective Activity of Phenylethanoids from Cistanche deserticola

Quanbo Xiong1 , Koji Hase1 , Yasuhiro Tezuka1 , Tadato Tani2 , Tsuneo Namba1 , Shigetoshi Kadota1
  • 1Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University, Toyama, Japan
  • 2Research Laboratories for High Quality of Life, Sumitomo Metal Industries, Ltd., Kyoto, Japan
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Publikationsverlauf

1997

1997

Publikationsdatum:
04. Januar 2007 (online)

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Abstract

Four phenylethanoids isolated from the stems of Cistanche deserticola, acteoside (1), 2′-acetylacteoside (2), isoacteoside (3) and tubuloside B (4), significantly suppressed NADPH/CCl4-induced lipid peroxidation in rat liver microsomes. Addition of them to primary cultured rat hepatocytes efficiently prevented cell damage induced by exposure to CCl4 or D-galactosamine (D-GaIN). Acteoside (1) further showed pronounced anti-hepatotoxic activity against CCl4 in vivo

Key words

Cistanche deserticola - Orobanchaceae - phenylethanoids - carbon tetrachloride - D-galactosamine - hepatoprotective activity