Cytotoxic and Antimalarial Alkaloids from Brunsvigia littoralis

William E. Campbell; Jerald J. Nair; David W. Gammon; Jaume Bastida; Carles Codina; Francesc Viladomat; Peter J. Smith; Carl F. Albrecht

doi:10.1055/s-2006-957381

Planta Med 1998; 64(1): 91-93
DOI: 10.1055/s-2006-957381

Letters

Cytotoxic and Antimalarial Alkaloids from Brunsvigia littoralis

William E. Campbell¹ , Jerald J. Nair¹ , David W. Gammon¹ , Jaume Bastida² , Carles Codina² , Francesc Viladomat² , Peter J. Smith³ , Carl F. Albrecht⁴

¹Department of Chemistry, University of Cape Town, Rondebosch, South Africa
²Department de Productes Naturals, Universitat de Barcelona, Barcelona, Spain
³Department of Pharmacology, University of Cape Town, Observatory, South Africa
⁴Department of Pharmacology, University of Stellenbosch, Tygerberg, South Africa

Abstract

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Abstract

Four known alkaloids, lycorine (1), 1,2-di-O-acetylly-corine (2), ambeiline (3), and crinine (4) were isolated from the bulbs of Brunsvigia littoralis (Amaryllidaceae). ¹H- and ¹³C-NMR spectra of 2 were completely assigned by means of ID- and 2D-NMR techniques. The alkaloids (1-4) together with the synthesised 11-O-acetylambelline (3a) and 3-O-acetylcrinine (4a) were tested for antimalarial activity with two strains of cultured Plasmodium falciparum and for cytotoxicity with BL6 mouse melanoma cells. Structures 1 and 2 exhibited both antimalarial and cytotoxic activity.

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