An Inhibitor of Aldose Reductase and Sorbitol Accumulation from Anthocepharus chinensis

Hiroyuki Haraguchi; Megumi Kanada; Ayumi Fukuda; Kaoru Naruse; Nobuyuki Okamura; Akira Yagi

doi:10.1055/s-2006-957369

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Planta Med 1998; 64(1): 68-69
DOI: 10.1055/s-2006-957369

Letters

An Inhibitor of Aldose Reductase and Sorbitol Accumulation from Anthocepharus chinensis

Hiroyuki Haraguchi¹ , Megumi Kanada¹ , Ayumi Fukuda¹ , Kaoru Naruse² , Nobuyuki Okamura² , Akira Yagi²

¹Faculty of Engineering, Fukuyama University, Gakuen-cho, Fukuyama, Japan
²Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Gakuen-cho, Fukuyama, Japan

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Publication History

1997

1997

Publication Date:
04 January 2007 (online)

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Abstract

A flavonoid glycoside was isolated from Anthocepharus chinensis. Its structure was elucidated by spectral data and determined to be myricetin 3-O-(4″-acetyl)-α-fucoside. This flavonoid glycoside and its aglycone showed potent inhibition against rat and porcine lens aldose reductase. The flavonoid aglycone also inhibited sorbitol accumulation in human red blood cells.