Planta Med 2006; 72(15): 1427-1430
DOI: 10.1055/s-2006-951711
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Antiplasmodial, Antimycobacterial, and Cytotoxic Principles from Camchaya calcarea

Namphung Vongvanich1 , Prasat Kittakoop2 , Panarat Charoenchai2 , Sutichai Intamas2 , Kanlayanee Sriklung2 , Yodhathai Thebtaranonth2
  • 1Department of Chemistry, Faculty of Science, Mahidol University, Bangkok, Thailand
  • 2National Center for Genetic Engineering and Biotechnology (BIOTEC), NSTDA, Klong Luang, Pathumthani, Thailand
Further Information

Publication History

Received: June 9, 2006

Accepted: September 11, 2006

Publication Date:
06 November 2006 (online)

Abstract

Chemical exploration of Camchaya calcarea (family Compositae) has led to the isolation of nine known sesquiterpene lactones 1 - 9, together with caffeic acid methyl ester 10. Sesquiterpenes 1, 2, 3, 4, 5, 7, and 8 exhibited moderate antiplasmodial activity, but showed potent antimycobacterial activity. Interestingly, the cytotoxicity of sesquiterpene lactones 1, 2, and 4 towards small-cell lung cancer cell line (NCI-H187) is stronger (two orders of magnitude) than towards the Vero cell line. Caffeic acid methyl ester (10) was cytotoxic against NCI-H187 and BC cell lines, however the ester 10 showed only mild antimycobacterial activity.

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Dr. Prasat Kittakoop

Chulabhorn Research Institute

Vipavadee-Rangsit Highway

Bangkok 10210

Thailand

Phone: +668-6-975-5777

Fax: +662-574-0622 ext. 1513

Email: prasatkittakoop@yahoo.com

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