Abstract
During batch cultivation, the cyanobacterial strain Synechocystis aquatilis Sauvageau B90.79 was found to release a fucose-rich sulfated polysaccharide, which
was mainly composed of arabinose (45 %) and fucose (47 %) and had a degree of sulfation
of 0.43. The released polysaccharide showed merely an anticoagulant activity of less
than 10 % compared to the reference compound, unfractionated heparin. However, distinctive
effects on the complement activation were observed: its inhibitory effect on the classical
pathway of complement activation was 600-fold stronger than that of unfractionated
heparin, whereas that on the alternative pathway of complement activation was 2- to
3-fold weaker. The results indicate that this biotechnologically producible, released
polysaccharide represents a specifically acting complement modulator.
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Dr. Rainer-B. Volk
Pharmaceutical Institute
University of Kiel
Gutenbergstraße 76
24118 Kiel
Germany
Phone: +49-431-880-1144
Fax: +49-431-880-1102
Email: volk@pharmazie.uni-kiel.de
