Biomimetic Syntheses of Lamellarin and Lukianol-Type Alkaloids

Abstract

The formation of 3,4-diarylpyrrole-2,5-dicarboxylic acids from arylpyruvic acids and 2-arylethylamines was used as a key step for the synthesis of several marine pyrrole alkaloids. The utility of this method is illustrated through the development of syntheses of ningalin B (5), lamellarins G (11a) and K (11b), lukianol A (32), and a lukianol-lamellarin hybrid (24).

biomimetic synthesis - marine alkaloids - pyrroles - lamellarins - lukianol A

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