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DOI: 10.1055/s-2006-949828
Screening of medical plants from Mali for antitrypanosomal activity
Dichlormethane extracts of 50 plant parts collected in Mali, traditionally used against trypanosomes were investigated for their in vitro and in vivo activity against Trypanosoma brucei brucei. [1]. Six extracts showed high efficacy in vitro, using the Long-term Viability Assay (LtVA) [2] with MIC-values of 50µg/mL. Four extracts showed low cytotoxicity and good tolerance in mice and were tested in vivo using the standard mouse test by Eisler et al. (2001), [3].
The extracts of Guiera senegalensis J.F. leaves and of Securidaca longependunculata Fres. roots were able to reduce parasitaemia in mice treated at a dose of 150mg/kg b.w. (i.p., two times daily for three days) with a reduction in parasitaemia of 42 and 48.5% compared to the untreated control group. These extracts are now phytochemicallly analysed for active principles.
Acknowledgements: The authors thank Dr. Bizimana for providing the plant material and for technical support.
References: 1. Bizimana, N. et al. (2006), J. Ethnopharmacol. 103: 350–356. 2. Kaminsky, R. et al. (1989), Exp. Parasitol. 69: 281–289. 3. Eisler, M.C. et al. (2001), Vet. Parasitol. 97: 171–182.