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Synlett 2006(13): 2151-2153  
DOI: 10.1055/s-2006-948184
LETTER
© Georg Thieme Verlag Stuttgart · New York

A Mitsunobu Diol Cyclisation to Chiral Morpholines and Dioxanes

Mark C. Wilkinson*, Rebecca Bell, Robert Landon, Petar O. Nikiforov, Andrew J. Walker
GlaxoSmithKline, Chemical Development, Medicines Research Centre, Gunnels Wood Road, Stevenage, SG1 2NY, UK
Fax: +44(1438)764869; e-Mail: Mark.C.Wilkinson@GSK.com;
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Publication History

Received 6 March 2006
Publication Date:
09 August 2006 (online)

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Abstract

A diol cyclisation under Mitsunobu conditions is presented, which allows access to chiral substituted morpholines and dioxanes.

Key words

Mitsunobu reaction - heterocycles - asymmetric - morpholines - pharmaceuticals

    References

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