Abstract
A safe and efficient method for catalytic H/D exchange to provide high deuterium incorporation
into a variety of aromatic substrates was developed. Systematic screening of the catalyst
and activator revealed that the essential activation of the Pd or Rh catalyst could
be achieved under safe and user friendly conditions. The application of this simple
catalytic method for the deuteration of bi- and tricyclic aromatic compounds and chiral
natural products was investigated.
Key words
deuterium - palladium - rhodium - heterogenous catalysis - alkaloids
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