Hinokiresinol Inhibits IgE-induced Mouse Passive Cutaneous Anaphylaxis Reaction

Abstract

The antiallergic effect of hinokiresinol isolated from the whole plant of Trapa pseudoincisa S. at. Z. was measured in vitro and in vivo. Hinokiresinol not only potently inhibited β-hexosaminidase release from RBL-2H3 cells induced by IgE, with an IC₅₀ value of 98 μM, but also inhibited the proinflammatory cytokines IL-6, IL-4 and TNF-α in RBL-2H3 cells stimulated by IgE. Orally and intraperitoneally administered hinokiresinol potently inhibited the passive anaphylaxis reaction in mice induced by IgE.

References

• 1 Wuthrich B. Epidemiology of the allergic diseases: are they really on the increase.  Int Arch Allergy Appl Immunol. 1989;  90 Suppl 1 3-10
• 2 Stevens R L, Austen K F. Recent advances in the cellular and molecular biology of mast cells.  Immunol Today. 1989;  10 381-6
• 3 Plaut M, Pierce J H, Whatson C, Hanley-Hyde J, Nordan R P, Paul W E. Mast cell lines produce lymphokines in response to cross-linkage of Fc epsilon RI or to calcium ionophore.  Nature. 1989;  339 64-7
• 4 Bruhns P, Fremont S, Daeron M. Regulation of allergy by Fc receptors.  Curr Opin Immunol. 2005;  17 662-9
• 5 Soka T. The Encyclopedia of Chinese Medicinal Herbs. 1st edition, Vol. 2 Tokyo; Shanghai Science and Technology Publishing Co 1985: 2708
• 6 Akagi M, Mio M, Tasaka K. Histamine release inhibition and prevention of the decrease in membrane fluidity induced by certain anti-allergic drugs: analysis of the inhibitory mechanism of NCO-650.  Agents Actions. 1983;  13 149-56
• 7 Simons F ER. The antiallergic effects of antihistamines.  J Allergy Clin Immunol. 1992;  90 705-15
• 8 Schafer-Korting M, Schmid M H, Korting H C. Topical glucocorticoids with improved risk-benefit ratio. Rationale of a new concept.  Drug Safety. 1996;  14 375-85
• 9 Bielory L. Complementary and alternative interventions in asthma, allergy, and immunology.  Ann Allergy Asthma Immunol. 2004;  93 Suppl 1 S45-54
• 10 Tsui W Y, Brown G D. (+)-Nyasol from Asparagus cochinchinensis .  Phytochemistry. 1996;  43 1413-5
• 11 Park H J, Lee J Y, Moo S S, Hwang B K. Isolation and anti-oomycete activity of nyasol from Anemarrhena asphodeloides rhizomes.  Phytochemistry. 2003;  64 997-1001
• 12 Choo M K, Park E K, Han M J, Kim D H. Antiallergic activity of ginseng and its ginsenosides.  Planta Med. 2003;  69 518-22
• 13 Gu B, DeAngelis L M. Enhanced cytotoxicity of bioreductive antitumor agents with dimethyl fumarate in human glioblastoma cells.  Anticancer Drugs. 2005;  16 167-74
• 14 Shin Y W, Bae E A, Kim D H. Effect of ginsenoside Rb1 and compound K in chronic oxazolone-induced mouse dermatitis.  Int Immunopharmacol. 2005;  5 1183-91
• 15 Mastuda H, Morikawa T, Ueda K, Managi H, Yoshikawa M. Structural requirement of flavonoids for inhibition of antigen-induced degranulation, TNF-α and IL-4 production from RNL-2H3 cells.  Bioorg Med Chem. 2002;  10 2123-8