PROFILE OF NEURONAL MIGRATION DISORDERS IN OMAN

Objectives: To review the profile of eighty cases of neuronal migration disorders at a university hospital.

Methods: The children with epilepsy, developmental delay, mental retardation or dysmorphism, who underwent neuroimaging (CT/MRI), as part of investigation formed the subjects of the study. The data was collected in children detected to have neuronal migration disorder. A routine CT/MRI was done. MRI included diffusion weighted images, FLAIR and occasionally MR angiography.

Results: There were 43(53.7%), 23male: 20 female cases of corpus callosum agenesis. Majority 41 were nonsyndromic. Epilepsy was in 17, microcephaly and groß developmental delay in 33. Nine children had associated other neuronal migration disorders. Lissencephaly was seen in 16(20%), 10male: 6 female, cases. Epilepsy was seen in 8(50%), associated other neuronal migration disorder was seen in 9(56.3%). Heterotopias were seen in 10(12.5%), 5male: 5 female, children. Epilepsy was in 7 and other neuronal migration disorder was seen in 5. Shizencephaly was observed in 5, 2male: 3 female. Epilepsy was in 4. Closed lip schizencephaly was in 3, open in 1 and bilateral in 2. Associated neuronal migration disorder was in 4. There were 3 cases of holoprosencephaly, 2 of polymicrogyria and 1 of hydranencephaly.

Conclusion: Most common neuronal migration disorder was corpus callosum agenesis. There was more than one anomaly in 28(35%) of cases. Four out of 5(80%), cases of schizencephaly had associated other neuronal migration disorder.