Neuropediatrics 2006; 37 - THP76
DOI: 10.1055/s-2006-945899

THE OUTCOME OF ACTH THERAPY FOR INFANTILE SPASMS

YH Zhang 1, GL Chen 1, J Qin 1, X Wu 1
  • 1Dept. of Pediatrics, First Hospital of Peking University, Beijing, P.R. China

Objectives: Follow up the IS patients treated with ACTH in order to analyze the long-term outcome and its influenced factors.

Methods: 1. The medical records of 53 patients with IS were analyzed with retrospective studies. 2. Fifty-three patients with IS, who were treated with ACTH, the dosage was ranged from 25IU to 40IU daily for 4 weeks, were analyzed.

Results: Factors influencing seizure outcome were treatment lag and the initial effects of ACTH on seizure, the patients with shorter treatment lag (=2 months) were better than those with longer treatment lag (>2 months), the patients with the better initial effects of ACTH on seizures were better than those with the worse initial effects of ACTH on seizures. Seizure outcome did not correlated with the age of onset and etiologies. Patients with shorter treatment lag (=2 months) showed a better mental outcome than those with longer treatment lag (>2 months). Cryptogenic group showed a better mental outcome than symptomatic group. Mental outcome in seizure-free patients were better than that in those having seizures. Mental outcome had not correlated with the age of onset and the initial effects of ACTH on seizures.

Conclusions: 1. The patients with shorter treatment lag and with the better initial effects of ACTH on seizures showed a better seizure outcome. 2. Mental outcome correlated with treatment lag, etiology and seizure outcome, patients with shorter treatment lag, cryptogenic and seizure-free showed a better mental outcome.