Neuropediatrics 2006; 37 - THP35
DOI: 10.1055/s-2006-945858

EFFECTS OF ANTIEPILEPTIC DRUGS ON BONE METABOLISM MARKERS IN CHILDREN'S MEDICAL CENTER

MR Ashrafi 1, F Khoshhal 1, A Rabbani 1, N Salajegheh 1, SE Nasrabady 1
  • 1Tehran University of Medical Science and Health Services, Tehran, Iran

Objectives: Assessment of unfavorable effects of antiepileptic drugs (AEDs) on bone metabolism in pediatric age group.

Methods: During a 20-month period, serum markers of bone metabolism [Calcium, Phosphate, Alkaline phosphatase (ALP) and Parathyroid hormone (PTH)] were measured in 119 patients who had been consuming AEDs for at least 6 months (age 4 to 15 years). The findings were then compared with the levels measured in 119 healthy controls.

Results: ALP was elevated in 23.5% of patients and was within normal range in the rest. PTH was elevated in 18.5% of patients, normal in 77.5% and decreased in 4.2%. ALP and PTH in patients group had been significantly elevated in comparison with control group (p-Value <0.05). Most elevated cases of ALP and PTH were observed in Carbamazepine consumers and the least were seen in Valproate Sodium consumers.

Conclusion: Regular measurement of calcium, phosphate, ALP and particularly PTH is recommended in the long-term consumption of AEDs.