NEUROPROTECTIVE ACTION OF CYCLOPENTYLADENOSINE AT THE CONVULSIVE STATE INDUCED BY INCREASE OF INTRACRANIAL PRESSURE

Objectives: Increase of intracranial pressure is one of actual problems of neurosurgery and neurology. The purpose of research there was a studying of neuroprotective action of selective agonist of adenosine receptors – cyclopentyladenosine (CPA) on new experimental model of acute intracranial hypertensia.

Methods: Work is carry out on 14 rats in weight of 100–120g. Increase of intracranial pressure modelled by intracerebroventricular injection of 0.04–0.05ml of 1% feracril solution. The CPA was injection intracerebroventricularly in a doze of 25 mkg / kg 60 minutes before injury (n=6). In the control animals group (n=8) we used introduction of physiological solution (NaCl, 0.9%). Estimation of neurological status was carried out during 120 minutes after feracril injection on 4 score scale (0-norm, 1- general cramps) and during five next day on 5 score scale (the 0-norm, 4- tetraplegia, death of animal). The data statistically analyzed with use of the U-test.

Results: In control group the average neurologic score for 120 minutes of supervision has made 1.63±0.07. The maximal neurologic changes have made 2.5±0.19 score (average duration of the maximal changes –36.25±7.3 minutes). The latent period of seizures has made 5.6±0.6 minutes. The average neurologic score for 5 day has made 3.3±5.7, lethality –87.5%. At use of CPA of seizure were marked at 2 of 8 animals. The average neurologic score for 120 minutes of supervision has made 0.1±0.02. The next five day the neurologic score has made 1.4±0.24 (P<0.005), lethality –33.3%.

Conclusion: Anticonvulsive action of CPA on this model can be connected as to decrease in an intracranial hypertensia, and suppression of convulsive neuronal activity.