Zusammenfassung
Akne ist weltweit die häufigste dermatologische Erkrankung. Um eine angesichts variierender
klinischer Bilder geeignete Therapie ansetzen zu können, sind gute Kenntnisse über
die Pathogenese der Erkrankung nötig. Acne vulgaris ist eine entzündliche Erkrankung,
bei deren Entstehung Androgene, PPAR-Liganden, regulierende Neuropeptide und Umweltfaktoren
beteiligt sein können. Diese Faktoren unterbrechen den natürlichen zyklischen Prozess
im Talgdrüsenfollikel und unterstützen den Übergang von Mikrokomedonen zu Komedonen
und entzündlichen Effloreszenzen. Proinflammatorische Lipide, Chemokine und Zytokine
übernehmen die Vermittlerrolle bei der Entwicklung von Akneeffloreszenzen. P. acnes ist in diesem Stadium nicht beteiligt, sondern kann später die entzündlichen Phänomene
verstärken.
Abstract
Acne is worldwide the most common skin disease. Suitable therapeutic regimens of the
varying clinical phenotypes require good knowledge of the pathogenesis of the illness.
Acne vulgaris is an inflammatory disorder at whose emergence androgens, PPAR ligands,
regulating neuropeptides and environmental factors are probably involved. These factors
interrupt the natural cycling process in the sebaceous gland follicle and support
the transition of microcomedones to comedones and inflammatory lesions. Proinflammatory
lipids, chemokines and cytokines overtake the role of mediators for the development
of acne lesions. P. acnes is not involved in this initial acne stages but can potentate the inflammatory phenomena
at a later stage.
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Prof. Dr. med. Christos C. Zouboulis
Hautklinik und Immunologisches Zentrum · Städtisches Klinikum Dessau
Auenweg 38 · 06847 Dessau
eMail: christos.zouboulis@klinikum-dessau.de
