Z Gastroenterol 2006; 44 - A29
DOI: 10.1055/s-2006-943396

The ATP-binding cassette transporter ABCG2 (BCRP) V12M and Q141K variants in Hungarian patients with IBD

P Fuszek 1, S Fischer 1, PL Lakatos 1, L Lakatos 2, A Kovacs 3, T Molnár 4, I Altorjay 5, M Papp 5, Á Szilvás 6, P Demeter 7, J Papp 1, R Schwab 8, A Tordai 6, H Andrikovics 6
  • 11st Department of Medicine, Semmelweis University
  • 21st Department of Medicine, Csolnoky F. County Hospital, Veszprem
  • 31st Department of Medicine, Erzsebet Hospital
  • 41st Department of Medicine, University of Szeged
  • 52nd Department of Medicine, University of Debrecen
  • 6Institute of Hematology and Immunology, National Medical Center, Budapest
  • 7Department of Gastroenterology, St Margit Hospital
  • 8Cooperative Research Center, Semmelweis University

Aim: ABCG2 is an important member of the multidrug resistance proteins, an 'ABC half transporter', and is modulating the absorption, cellular efficacy and toxicity of several pharmacological agents. Since no data are available in IBD, our aim was to study the ABCG2 V12M and Q141K variants and response to medical therapy and/or disease phenotype in Hungarian IBD patients.

Methods: 351 unrelated IBD patients (CD: 212, age 35.7±12.6 years; UC: 139, age 43.8±15.4years) and 149 healthy subjects were investigated. ABCG2 V12M and Q141K SNPs were detected by real-time PCR. Detailed clinical phenotype was determined.

Results: The frequency of the V12M and Q141K variant alleles were not significantly different in CD (6.3% and 10.1%) and UC (3.9% and 12.3%) compared to the controls (4.0% and 9.4%). In CD, there was a tendency for decreased use of azathioprine in carriers of variant ABCG2 alleles (57.3% vs. 68.9%, OR:0.59, 95%CI:0.32–1.10). No other phenotype-genotype associations were found, as well as the presence of the variant allele did not predict the response to steroid/infliximab therapy. In UC, there was a tendency for the 141K variant allele to be preventive for arthritis (15.1% vs. 30.2%, OR:0.41, 95%CI: 0.15–1.16). The risk for steroid resistance was not significantly reduced in patients carrying ABCG2 variant alleles (13.3% vs. 27.7%, p=NS).

Conclusions: ABCG2 V12M and Q141K variants were not associated to IBD in Hungarian patients, as well as the carriage of variant alleles did not predict the response to medical therapy or need for surgery.