Colorectal Lymphoma

ABSTRACT

Lymphoma involving the colon and rectum is rare and can occur either as primary colorectal lymphoma or as a manifestation of systemic disease. Most patients with primary colorectal lymphoma present with abdominal pain, and obstruction is unusual. Although lesions may be evident on radiographic studies, the findings are generally nonspecific. Historically, aggressive B-cell lymphomas have been the most common gastrointestinal lymphomas reported in the literature. However, recent reports suggest increased rates of mucosa-associated lymphoid tissue (MALT) lymphoma and mantle cell lymphoma (MCL) with increased surveillance.[1] Most patients with colorectal lymphoma undergo surgery, but multiagent chemotherapy remains the mainstay of treatment. B-cell lymphomas tend to be most aggressive, with a median survival of about 2 years.

KEYWORDS

Lymphoma - immunosuppression

REFERENCES

• 1 American Cancer Society .Cancer Facts and Figures. Atlanta, GA; American Cancer Society 2005
• 2 Zucca E, Roggero E, Bertoni F et al.. Primary extranodal non-Hodgkin's lymphomas. Part 1: Gastrointestinal, cutaneous and genitourinary lymphomas.  Ann Oncol. 1997;  8 727-737
• 3 Koch P, del Valle F, Berdel W E et al.. Primary gastrointestinal non-Hodgkin's lymphoma: I. Anatomic and histologic distribution, clinical features, and survival data of 371 patients registered in the German Multicenter Study GIT NHL 01/92.  J Clin Oncol. 2001;  19 3861-3873
• 4 Doolabh N, Anthony T, Simmang C et al.. Primary colonic lymphoma.  J Surg Oncol. 2000;  74 257-262
• 5 Fan C W, Changchien C R, Wang J Y et al.. Primary colorectal lymphoma.  Dis Colon Rectum. 2000;  43 1277-1282
• 6 Dawson I, Cornes J, Morson B. Primary malignant lymphoid tumors of the intestinal tract. Report of 37 cases with a study of factors influencing prognosis.  Br J Surg. 1961;  49 80-89
• 7 Harris N L, Jaffe E S, Diebold J et al.. Lymphoma classification-from controversy to consensus: the R.E.A.L. and WHO Classification of lymphoid neoplasms.  Ann Oncol. 2000;  11(Suppl 1) 3-10
• 8 Zighelboim J, Larson M V. Primary colonic lymphoma. Clinical presentation, histopathologic features, and outcome with combination chemotherapy.  J Clin Gastroenterol. 1994;  18 291-297
• 9 Armitage J O, Weisenburger D D. New approach to classifying non-Hodgkin's lymphomas: clinical features of the major histologic subtypes. Non-Hodgkin's Lymphoma Classification Project.  J Clin Oncol. 1998;  16 2780-2795
• 10 Romaguera J E, Medeiros L J, Hagemeister F B et al.. Frequency of gastrointestinal involvement and its clinical significance in mantle cell lymphoma.  Cancer. 2003;  97 586-591
• 11 Okada M, Maeda K, Suzumiya J et al.. Primary colorectal T-cell lymphoma.  J Gastroenterol. 2003;  38 376-384
• 12 Carbone P P, Kaplan H S, Musshoff K et al.. Report of the Committee on Hodgkin's Disease Staging Classification.  Cancer Res. 1971;  31 1860-1861
• 13 Contreary K, Nance F C, Becker W F. Primary lymphoma of the gastrointestinal tract.  Ann Surg. 1980;  191 593-598
• 14 Rohren E M, Turkington T G, Coleman R E. Clinical applications of PET in oncology.  Radiology. 2004;  231 305-332
• 15 DeVita Jr V T, Canellos G P, Chabner B et al.. Advanced diffuse histiocytic lymphoma, a potentially curable disease.  Lancet. 1975;  1 248-250
• 16 Cowan R A, Jones M, Harris M et al.. Prognostic factors in high and intermediate grade non-Hodgkin's lymphoma.  Br J Cancer. 1989;  59 276-282
• 17 Gordon L I, Harrington D, Andersen J et al.. Comparison of a second-generation combination chemotherapeutic regimen (m-BACOD) with a standard regimen (CHOP) for advanced diffuse non-Hodgkin's lymphoma.  N Engl J Med. 1992;  327 1342-1349
• 18 Fisher R I, Gaynor E R, Dahlberg S et al.. Comparison of a standard regimen (CHOP) with three intensive chemotherapy regimens for advanced non-Hodgkin's lymphoma.  N Engl J Med. 1993;  328 1002-1006
• 19 Mauch P, Leonard R, Skarin A et al.. Improved survival following combined radiation therapy and chemotherapy for unfavorable prognosis stage I-II non-Hodgkin's lymphomas.  J Clin Oncol. 1985;  3 1301-1308
• 20 Aviles A, Neri N, Huerta-Guzman J. Large bowel lymphoma: an analysis of prognostic factors and therapy in 53 patients.  J Surg Oncol. 2002;  80 111-115