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Synfacts 2006(7): 0639-0639  
DOI: 10.1055/s-2006-941832
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Diversonol

Contributor(s): Philip Kocienski, Thomas Snaddon
C. F. Nising, U. K. Ohnemüller, S. Bräse*
Universität Karlsruhe, Germany
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Publication History

Publication Date:
22 June 2006 (online)

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Significance

Diversonol, a secondary metabolite isolated from Penicillium diversum, possesses a carbon scaffold also found in the secalonic acids, isolated from Claviceps purpurea. These myco­toxins exhibit a variety of biological activities and the development of efficient routes to their synthesis is desirable. Noteworthy in this synthesis is the oxa-Michael-aldol condensation (B. Lesch, S. Bräse Angew. Chem. Int. Ed. 2004, 43, 115-118) used to prepare tetraoxanthenone B.