ABSTRACT
Nearly 32 million Americans have migraine, 24 million of whom are women who suffer
with migraine throughout their lifetimes. Prior to puberty, girls are afflicted with
migraine at approximately the same rate as boys, but after puberty there is an emerging
female predominance. Although hormones do not entirely explain the epidemiological
variation seen in migraine, estrogen certainly plays an important role. Given the
hormonal changes occurring throughout a woman's life, there are many opportunities
for a hormonal impact on migraine, including menarche, oral contraceptive use, pregnancy,
perimenopause, and menopause. The special considerations of migraine in women will
be reviewed including epidemiology, pathophysiology, diagnosis, and therapy.
KEYWORDS
Hormones - menstrual migraine - pregnancy - menopause - contraceptives
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Christine L LayM.D.
The Headache Institute, St. Luke's-Roosevelt Hospital Center
1000 Tenth Avenue, Suite 1C-10, New York, NY 10019