Synthesis 2006(10): 1701-1704  
DOI: 10.1055/s-2006-926451
SPECIALTOPIC
© Georg Thieme Verlag Stuttgart · New York

Asymmetric Synthesis of Trifluoromethylphenyl Cyclopropanes Catalyzed by Chiral Metalloporphyrins

Paul Le Maux, Sandrine Juillard, Gérard Simonneaux*
Laboratoire Sciences Chimiques de Rennes, UMR CNRS 6226, Campus de Beaulieu, Université de Rennes 1, 35042 Rennes, France
Fax: +33(223)235637; e-Mail: gerard.simonneaux@univ-rennes1.fr;
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Publikationsverlauf

Received 24 March 2006
Publikationsdatum:
27. April 2006 (online)

Abstract

The asymmetric addition of 2,2,2-trifluorodiazoethane to styrene derivatives to give optically active trifluoromethylphenyl cyclopropanes (ee values up to 69%) was carried out by using chiral iron and ruthenium porphyrins as homogeneous and heterogeneous catalysts.