The Triphenyl Phosphite-Chlorine Reagent in the Synthesis of Pyrroles from N-Allylamides

Alberto Spaggiari; Daniele Vaccari; Paolo Davoli; Fabio Prati

doi:10.1055/s-2006-926365

PAPER

The Triphenyl Phosphite-Chlorine Reagent in the Synthesis of Pyrroles from N-Allylamides

Alberto Spaggiari, Daniele Vaccari, Paolo Davoli, Fabio Prati*
Dipartimento di Chimica, Università di Modena e Reggio Emilia, via Campi 183, 41100 Modena, Italy
Fax: +39(059)373543; e-Mail: prati.fabio@unimore.it;

Abstract

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Abstract

A novel application of (PhO)₃P-Cl₂ chemistry to the synthesis of 2-substituted and 2,3-disubstituted pyrroles from N-allylamides is illustrated. A mild procedure is used to generate the imino chloride intermediates, which are subsequently cyclized to pyrroles. The products are smoothly obtained in moderate to good overall yields.

Key words

triphenyl phosphite - chlorine - pyrroles - allylamides - cyclizations

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Referenzen

References

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