Conversion of Nucleophilic Halides to Electrophilic Halides: Efficient and Selective Halogenation of Azinones, Amides, and Carbonyl Compounds Using Metal Halide/Lead Tetraacetate

Jeum-Jong Kim; Deok-Heon Kweon; Su-Dong Cho; Ho-Kyun Kim; Sang-Gyeong Lee; Yong-Jin Yoon

doi:10.1055/s-2006-926224

LETTER

Conversion of Nucleophilic Halides to Electrophilic Halides: Efficient and Selective Halogenation of Azinones, Amides, and Carbonyl Compounds Using Metal Halide/Lead Tetraacetate

Jeum-Jong Kim^a, Deok-Heon Kweon^a, Su-Dong Cho*^a, Ho-Kyun Kim^a, Sang-Gyeong Lee^b, Yong-Jin Yoon*^a
^a Department of Chemistry & Environmental Biotechnology National Core Research Center, Gyeongsang National University, Chinju 660-701, Korea
Fax: +82(55)7610244; e-Mail: yjyoon@gsnu.ac.kr;
^b Department of Chemistry & Research Institute of Life Science Gyeongsang National University, Chinju 660-701, Korea

Abstract

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Abstract

AlCl₃/Pb(OAc)₄ and ZnBr₂/Pb(OAc)₄ are efficient electrophilic N- and α-C-halogenating agents. A variety of azinones, amides and carbonyl compounds were chemoselectively and regioselectively N-, or α-C-halogenated in good to excellent yield using AlCl₃/Pb(OAc)₄ and ZnBr₂/Pb(OAc)₄ in acetonitrile.

Key words

N-halogenation, - α-C-halogenation - electrophilic halogenation - selective halogenation - metal halide/lead tetraacetate

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References

References and Notes

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Typical N-Chlorination of Azinones, Amides and Carbonyl Compounds.
Pb(OAc)₄ (2.0 or 4.0 mmol) was dissolved in MeCN (20 mL). AlCl₃ or ZnCl₂ (2.0 or 4.0 mmol) was added to the MeCN solution, and the mixture was stirred for 5 min at r.t. After adding the nitrogen heterocycle (2 mmol) or carbonyl compound (2 mmol) to the above solution, the resulting mixture was refluxed until nitrogen heterocycle or carbonyl compound was disappeared. After evaporating the solvent under reduced pressure, the resulting residue was applied to the top of an open-bed silica gel column (3.0 × 7 cm). The column was eluted with CH₂Cl₂ or CH₂Cl₂-n-hexane (1:1). Fractions containing the product were combined and evaporated under reduced pressure to give monochlorides and/or dichlorides.
Selected Analytical Data.2,4,5-Trichloropyridazin-3(2 H )-one: colorless crystals (CH₂Cl₂); mp 146-147 °C (lit. [21] 146-147 °C). TLC (CH₂Cl₂): R _f = 0.5. IR (KBr): 3100, 1700, 1600, 1580, 1360, 1260, 1180, 1160, 960 cm^-1. ¹H NMR (CDCl₃): δ = 7.76 (s, 1 H) ppm. ¹³C NMR (CDCl₃): δ = 134.8, 137.0, 137.5, 153.8 ppm. Anal. Calcd for C₄HCl₃N₂O: C, 24.09; H, 0.51; N, 14.05. Found: C, 24.10; H, 0.53; N, 14.07.
N -Chloroisoindole-1,3-dione: colorless crystals (CH₂Cl₂); mp 184-185 °C. TLC (CH₂Cl₂): R _f = 0.73. IR (KBr): 3070, 2950, 2880, 1750, 1720, 1620, 1510, 1470, 1360, 1310, 1080, 860 cm^-1. ¹H NMR (CDCl₃): δ = 7.82-7.84 (m, 2 H), 7.89-7.93 (m, 2 H) ppm. ¹³C NMR (CDCl₃): δ = 123.9, 131.0, 134.7, 163.3 ppm. Anal. Calcd for C₈H₄ClNO₂: C, 52.92; H, 2.22; N, 7.71. Found: C, 52.98; H, 2.24; N, 7.79.
N , N -Dichlorotoluene-4-sulfonamide: colorless crystals (CH₂Cl₂); mp 130-131 °C. TLC (CH₂Cl₂): R _f = 0.57. IR (KBr): 3100, 3070, 1860, 1770, 1600, 1470, 1360, 1250, 1100, 910 cm^-1. ¹H NMR (CDCl₃): δ = 7.91-7.95 (m, 2 H), 8.02-8.06 (m, 2 H) ppm. ¹³C NMR (CDCl₃): δ = 125.7, 131.3, 136.1, 162.8 ppm. Anal. Calcd for C₈H₄Br₂N₂O₂: C, 30.03; H, 1.26; N, 8.76. Found: C, 30.11; H, 1.30; N, 8.82.
2-Acetyl-2-chloro-3,4-dihydro-2 H -naphthalen-1-one: colorless crystals (CH₂Cl₂-n-hexane = 1:1); mp 49-50 °C (lit. [21] mp 48-50 °C). TLC (CH₂Cl₂-n-hexane = 1:1): R _f = 0.51. IR (KBr): 2950, 1720, 1680, 1600, 1460, 1420, 1360, 1300, 1240, 1200, 900, 850, 750, 720 cm^-1. ¹H NMR (CDCl₃): δ = 2.42 (s, 3 H), 2.45-2.51 (m, 1 H), 2.90-2.99 (m, 1 H), 3.05-3.08 (m, 1 H), 3.12-3.16 (m, 1 H), 7.41-7.46 (m, 2 H), 7.63-7.69 (m, 1 H), 7.95 (d, 1 H, J = 7.8 Hz) ppm. ¹³C NMR (CDCl₃): δ = 25.0, 26.6, 30.0, 75.9, 127.3, 127.7, 129.2, 129.5, 134.7, 142.9, 189.3, 201.0 ppm. Anal. Calcd for C₁₂H₁₁ClO₂: C, 64.73; H, 4.98. Found: C, 64.75; H, 4.99.
2,2-Dichloro-1-phenylbutane-1,3-dione: colorless crystals (CH₂Cl₂-n-hexane = 1:2); mp 75-76 °C (lit. [21] mp 75-76 °C). TLC (CH₂Cl₂-n-hexane = 1:2): R _f = 0.50. IR (KBr): 3070, 2930, 2880, 1760, 1730, 1710, 1680, 1600, 1580, 1510, 1450, 1360, 1250, 1230, 840, 780, 690, 660, 580 cm^-1. ¹H NMR (CDCl₃): δ = 2.47 (s, 3 H), 7.46-7.54 (m, 2 H), 7.61-7.67 (m, 1 H), 8.06-8.10 (m, 2 H) ppm. ¹³C NMR (CDCl₃): δ = 24.9, 86.5, 128.7, 130.6, 130.9, 134.5, 185.9, 192.2 ppm. Anal. Calcd for C₁₀H₈Cl₂O₂: C, 51.98; H, 3.49. Found: C, 51.99; H, 3.52.
2,2-Dichloroindan-1,3-dione: colorless crystals (CH₂Cl₂-n-hexane = 1:1); mp 125-126 °C. TLC (CH₂Cl₂-n-hexane = 1:1): R _f = 0.63. IR (KBr): 3100, 3060, 2930, 2880, 1780, 1740, 1600, 1260, 1160, 870, 810, 780, 650 cm^-1. ¹H NMR (CDCl₃): δ = 8.07-8.11 (m, 2 H), 8.13-8.17 (m, 2 H) ppm. ¹³C NMR (CDCl₃): δ = 72.8, 125.8, 137.0, 138.1, 186.4 ppm. Anal. Calcd for C₈H₄Cl₂O₂: C, 50.27; H, 1.87. Found: C, 50.29; H, 1.91.

Typical N-Bromination of Azinones, Amides and Carbonyl Compounds.
Pb(OAc)₄ (2.0 or 4.0 mmol) was dissolved in MeCN (20 mL). ZnBr₂ (2.0 or 4.0 mmol) was added to the MeCN solution, and the mixture was stirred for 5 min at r.t. The nitrogen heterocycle (2 mmol) or carbonyl compound (2 mmol) was added to the resulting solution. The resulting mixture was stirred at r.t. until nitrogen heterocycle or carbonyl compound disappeared. After evaporating the solvent under reduced pressure, the resulting residue was applied to the top of an open-bed silica gel column (3.0 × 7 cm). The column was eluted with CH₂Cl₂ or CH₂Cl₂-n-hexane (1:1). Fractions containing the product were combined and evaporated under reduced pressure to give monobromides or dibromides. Selected Analytical Data.
2-Bromo-3,4-dichloropyridazin-3(2 H )-one: colorless crystals (CH₂Cl₂); mp 169 °C. IR (KBr): 3100, 1690, 1600, 1460, 1400, 1300, 1260, 1120, 960 cm^-1. ¹H NMR (CDCl₃): δ = 7.50 (s, 1 H) ppm. ¹³C NMR (CDCl₃): δ = 132.3, 136.2, 154.7, 168.0 ppm. Anal. Calcd for C₄HBrCl₂N₂O: C, 19.70; H, 0.41; N, 11.49. Found: C, 19.76; H, 0.43; N, 11.51.
N -Bromoisoindole-1,3-dione: colorless crystals (CH₂Cl₂); mp 199-200 °C (lit. [33] mp 198-202 °C). TLC (CH₂Cl₂): R _f = 0.76. IR (KBr): 3090, 3050, 1775, 1730, 1690, 1610, 1460, 1350, 1290, 1100, 1070, 860, 800, 700 cm^-1. ¹H NMR (CDCl₃): δ = 7.73-7.77 (m, 2 H), 7.88-7.91 (m, 2 H) ppm. ¹³C NMR (CDCl₃): δ = 123.8, 131.9, 134.3, 165.0 ppm. Anal. Calcd for C₈H₄BrNO₂: C, 42.51; H, 1.78; N, 6.20. Found: C, 42.59; H, 1.84; N, 6.27.
2,3-Dibromophthalazine-1,4-dione: colorless crystals (CH₂Cl₂); mp 130-131 °C. TLC (CH₂Cl₂): R _f = 0.57. IR (KBr): 3100, 3070, 1860, 1770, 1600, 1470, 1360, 1250, 1100, 910 cm^-1. ¹H NMR (CDCl₃): δ = 7.91-7.95 (m, 2 H), 8.02-8.06 (m, 2 H) ppm. ¹³C NMR (CDCl₃): δ = 125.7, 131.3, 136.1, 162.8 ppm. Anal. Calcd for C₈H₄Br₂N₂O₂: C, 30.03; H, 1.26; N, 8.76. Found: C, 30.11; H, 1.30; N, 8.86.
2-Bromo-1-phenylbutane-1,3-dione: colorless oil. TLC (CH₂Cl₂): R _f = 0.52. IR (KBr): 3080, 2970, 2940, 1720, 1680, 1600, 1450, 1360, 1300, 1230, 1190, 1000, 760, 690, 550 cm^-1. ¹H NMR (CDCl₃): δ = 2.44 (s, 3 H), 5.67 (s, 1 H), 7.46-7.52 (dd, 2 H, J = 7.87, 7.41 Hz), 7.50-7.65 (m, 1 H), 7.95-7.98 (m, 2 H) ppm. ¹³C NMR (CDCl₃): δ = 27.2, 53.0, 128.6, 129.0, 129.2, 134.5, 190.0, 198.1 ppm. Anal. Calcd for C₁₀H₈BrO₂: C, 49.82; H, 3.76. Found: C, 49.84; H, 3.80.
2,2-Dibromomalonic Acid Diethyl Ester: colorless oil. TLC (CH₂Cl₂-n-hexane = 1:1): R _f = 0.50. IR (KBr): 2980, 2930, 2890, 1760, 1740, 1465, 1445, 1390, 1365, 1290, 1240, 1200 cm^-1. ¹H NMR (CDCl₃): δ = 1.32-1.37 (t, 6 H, J = 7.13 Hz), 4.33-4.41 (q, 4 H, J = 7.13 Hz) ppm. ¹³C NMR (CDCl₃): δ = 13.7, 50.7, 64.7, 163.1 ppm. Anal. Calcd for C₇H₁₀Br₂O₄: C, 26.44; H, 3.17. Found: C, 26.50; H, 3.20.

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