Erratum zu diesem Artikel:
ErratumHorm Metab Res 2006; 38(09): 617-617
DOI: 10.1055/s-2006-956173
Abstract
Somatostatin (SRIF) is a widely distributed peptide with growth-inhibiting effects
in various tumors. So far, five distinct human SRIF receptor subtypes (sst1 - sst5) have been identified. We investigated expression of the five ssts in various adrenal tumors and in normal adrenal gland. Tissue was obtained from ten
pheochromocytomas (PHEOs), nine cortisol-secreting adenomas (CPAs), eleven aldosterone
secreting adenomas (APAs) and eight non-functional adenomas (NFAs) after retroperitoneoscopic
surgery, and used for RNA extraction. Adrenal tissue surrounding the tumor was available
for analysis in twenty-seven cases. Receptor expression was studied by RT-PCR using
sst-specific primers and subsequently confirmed by Southern blotting. Expression of all
five receptor subtypes was observed in RNA obtained from normal adrenal gland. Furthermore,
each receptor subtype was expressed in more than 50 % of all tumors analyzed. No sst5 expression was found in PHEOs, while sst1 was present in nearly all of these tumors. Only a few of the CPAs expressed subtypes
sst1 and sst4. Expression of all five subtypes was distributed equally in APAs. No sst4 was found in any of the NFAs. Differential expression of ssts in various adrenal tumors may point to new aspects in the pathogenesis of these adenomas.
Furthermore, the presence of specific ssts could expand the diagnostic and therapeutic strategies during management. New subtype
specific analogues of SRIF may be used in the future depending on the type of adrenal
tumor and receptor subtype expressed.
Key words
Somatostatin receptor - somatostatin analogues - adrenal gland - adrenal tumor - pheochromocytoma
- aldosterone - cortisol - expression
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PD Dr. med. Stephan Petersenn
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