Abstract
A series of 1′-homocarbanucleosides was prepared by coupling a purine or pyrimidine
to, or constructing it on, a protected 1-methylcyclopenta[c ]pyrazole pseudosugar synthesized from (±)-(exo ,exo )-1-methyl-4,5,6,7-tetrahydro-4,7-methanoindazole-5,6-diol by oxidative cleavage of
the starting glycol, reduction of the resulting dialdehyde with NaBH4 , and the protective monosilylation of the bis(hydroxymethyl) reduction product.
Key words
methanoindazoles - 1′(N )-homocarbanucleosides - nucleoside analogues - methylcyclopenta[c ]pyrazol - glycol cleavage - silyl ethers
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