ABSTRACT
Recent evidence suggests that intensive follow-up after curative resection of colorectal
cancer is associated with a small but significant improvement in survival. Regimens
that employ cross-sectional imaging and carcinoembryonic antigen determination appear
to have the greatest benefit. A risk-adapted approach to follow-up, intensively following
patients at highest risk of recurrence, increases efficacy and cost-effectiveness.
Ongoing improvements in risk stratification, disease detection, and treatment will
increase the benefits of postoperative surveillance. Large randomized controlled trials
are needed to determine the optimal surveillance regimen and must include an analysis
of survival, quality of life, and cost-effectiveness to assess efficacy properly.
KEYWORDS
Colorectal neoplasm - neoplasm recurrence/detection - neoplasm metastasis/diagnosis
- surveillance - follow-up - survival
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W. Donald BuieM.D.
Foothills Hospital/SSB Rm. AC144D
1403 29th St., NW, Calgary, AB T2N 2T9 Canada
Email: wdbuie@ucalgary.ca