The Effects of Ginsenoside Re and its Metabolite, Ginsenoside Rh1, on 12-O-Tetradecanoylphorbol 13-acetate- and Oxazolone-Induced Mouse Dermatitis Models

Abstract

The effects of the main constituent ginsenoside Re in ginseng and its metabolite, ginsenoside Rh1, were investigated in 12-O-tetradecanoylphorbol 13-acetate (TPA)- and oxazolone-induced mouse ear dermatitis models. Ginsenoside Rh1 potently suppressed the TPA- and oxazolone-induced swellings as well as mRNA expression levels of cyclooxygenase-2, IL-1β and TNF-α, although these were only weakly inhibited by ginsenoside Re.

Abbreviations

TPA:12-O-tetradecanoilphorbol 13-acetate

COX:cyclooxygenase

TNF-α:tumor necrosis factor-α

IL-1β:interleukin-1β

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