An efficient synthesis of pyranonaphthoquinones is achieved by ethylenediamine diacetate-catalyzed
reactions of 4-hydroxy-2-quinolones with a variety of α,β-unsaturated aldehydes in
moderate yields. This method provides a rapid entry into biologically interesting
α-lapachone derivatives with a variety of substituents on the pyran ring.
pyranonaphthoquinones - ethylenediamine diacetate - tandem Knoevenagel-electrocyclic
reaction - α-lapachone derivatives
