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Klinische Neurophysiologie 2005; 36(4): 186-201
DOI: 10.1055/s-2005-915325
Originalia
© Georg Thieme Verlag KG Stuttgart · New York

Therapeutische Anwendung der repetitiven transkraniellen Magnetstimulation in der Neurologie - Möglichkeiten und Grenzen

Therapeutic Applications of Repetitive Transcranial Magnetic Stimulation in Neurological Disorders - Potential and LimitationsM.  Pötter1 , M.  Peller1 , 2 , H.  R.  Siebner1 , 2
  • 1Klinik für Neurologie, Christian-Albrechts-Universität, Kiel
  • 2NeuroImage-Nord, Hamburg-Kiel-Lübeck
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Publication History

Publication Date:
08 December 2005 (online)

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Zusammenfassung

Dieses Übersichtsreferat fasst den derzeitigen Kenntnisstand zum therapeutischen Einsatz der repetitiven transkraniellen Magnetstimulation (rTMS) in der Neurologie zusammen. Zunächst beschreiben wir die derzeit bekannten neuromodulatorischen Effekte der rTMS im gesunden Gehirn und leiten daraus Konzepte für den therapeutischen Einsatz der rTMS bei neurologischen Erkrankungen ab. Es folgt eine Zusammenfassung der Studien, welche die rTMS bei Patienten mit Morbus Parkinson, chronischen Schmerzen oder Tinnitus eingesetzt haben, um eine motorische oder sensorische Dysfunktion zu behandeln. Anhand dieser Beispiele werden die Grenzen der derzeitigen Therapieversuche dargelegt. Als Ausblick werden Forschungsansätze aufgezeigt, die helfen können, die neurobiologischen Effekte der rTMS im erkrankten Gehirn besser zu verstehen und die therapeutische Effizienz der rTMS zu steigern.

Abstract

This paper reviews the current knowledge regarding the therapeutic application of repetitive transcranial magnetic stimulation (rTMS) in the field of clinical neurology. First, we summarize the neuromodulatory effects of rTMS in the healthy brain and outline the concepts behind the therapeutic use of rTMS. Second, we review clinical trials that have used rTMS to improve motor dysfunction in patients with Parkinson's disease or to reduce sensory dysfunction in patients with chronic pain or tinnitus. Based on this work, we discuss the main limitations of current attempts to treat neurological disorders with rTMS. Finally, we outline future avenues of research that will provide deeper insights into the neurobiological changes induced by rTMS and help to increase the therapeutic efficacy of rTMS.

Key words

Neuromodulation - Parkinson's disease - pain - tinnitus - therapy - transcranial magnetic stimulation

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Prof. Dr. med. Hartwig Roman Siebner

Christian-Albrechts-Universität zu Kiel

Schittenhelmstraße 10

24105 Kiel

Email: h.siebner@neurologie.uni-kiel.de

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