Planta Med 2006; 72(2): 132-135
DOI: 10.1055/s-2005-873192
Original Paper
Pharmacology
© Georg Thieme Verlag KG Stuttgart · New York

Antimicrobial Principle from Aframomum longifolius

Simplice Joel Ndendoung Tatsimo1 , Pierre Tane2 , Jacob Melissa3 , Beibam L. Sondengam1 , Christopher O. Okunji4 , 5 , Brian M. Schuster5 , Maurice M. Iwu4 , 5 , Ikhlas A. Khan3
  • 1Department of Organic Chemistry, University of Yaounde, Yaounde, Cameroon
  • 2Department of Chemistry, University of Dschang, Dschang, Cameroon
  • 3National Center for Natural Products Research, The University of Mississippi, University, MS, USA
  • 4International Centre for Ethnomedicine and Drug Development, Nsukka, Nigeria; and Bioresources Development & Conservation Programme, Silver Spring, MD, USA
  • 5Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Washington DC, USA
Further Information

Publication History

Received: October 17, 2004

Accepted: July 18, 2005

Publication Date:
05 December 2005 (online)

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Abstract

Antimicrobial activity-directed fractionation of the seeds of Aframomum longifolius (Zingiberaceae) afforded two new labdane-type diterpenoids, 15-hydroxy-15-methoxylabda-8(17), 12(E)-dien-16-al (aframolin A) (1) and 8β(17)-epoxy-15,15-dimethoxylabd-12(E)-en-16-al (aframolin B) (2), together with the known diterpenes labda-8(17),12(E)-diene-15,16-dial (3) and aframodial (4). Their structures were determined by spectroscopic methods. Compound 4 showed significant antimicrobial activity against Cryptococcus neoformans, Staphylococcus aureus and methicillin-resistant S. aureus (MRS) while 1, 2 and 3 were found to be inactive.

References

Dr. Ikhlas A. Khan

National Center for Natural Products Research

The University of Mississippi

University

MS 38677-1848

USA

Fax: +1-662-915-7989

Email: ikhan@olemiss.edu